After studying the 13 games on the Week 12 card in the NFL, our best against-the-spread choice is Cardinals -1. For more tips, which could lead to parlay possibilities, see below.

NFL Picks Against the Spread – Week 12

Jump to Matchup:

Pick: Cardinals -1 vs. Seahawks

• Matchup: Arizona Cardinals at Seattle Seahawks
• Projected Winner & Margin: Cardinals by 3.1 points (Bet on this game at BetMGM)
• Spread: Cardinals -1
• Time: 4:25 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers -2.5 vs. 49ers

• Matchup: San Francisco 49ers at Green Bay Packers
• Projected Winner & Margin: Packers by 9.3 points (Bet on this game at BetMGM)
• Spread: Packers -2.5
• Time: 4:25 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Eagles -3 vs. Rams

• Matchup: Philadelphia Eagles at Los Angeles Rams
• Projected Winner & Margin: Eagles by 3.5 points (Bet on this game at BetMGM)
• Spread: Eagles -3
• Time: 8:20 p.m. ET
• Date: Nov. 24
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chargers +3 vs. Ravens

• Matchup: Baltimore Ravens at Los Angeles Chargers
• Projected Winner & Margin: Chargers by 2.3 points (Bet on this game at BetMGM)
• Spread: Ravens -3
• Time: 8:15 p.m. ET
• Date: Nov. 25
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -3.5 vs. Browns

• Matchup: Pittsburgh Steelers at Cleveland Browns
• Projected Winner & Margin: Steelers by 16.4 points (Bet on this game at BetMGM)
• Spread: Steelers -3.5
• Time: 8:15 p.m. ET
• Date: Nov. 21
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Vikings -3.5 vs. Bears

• Matchup: Minnesota Vikings at Chicago Bears
• Projected Winner & Margin: Vikings by 10.1 points (Bet on this game at BetMGM)
• Spread: Vikings -3.5
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers -5.5 vs. Giants

• Matchup: Tampa Bay Buccaneers at New York Giants
• Projected Winner & Margin: Buccaneers by 11.3 points (Bet on this game at BetMGM)
• Spread: Buccaneers -5.5
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos -5.5 vs. Raiders

• Matchup: Denver Broncos at Las Vegas Raiders
• Projected Winner & Margin: Broncos by 11.7 points (Bet on this game at BetMGM)
• Spread: Broncos -5.5
• Time: 4:05 p.m. ET
• Date: Nov. 24
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Patriots +7 vs. Dolphins

• Matchup: New England Patriots at Miami Dolphins
• Projected Winner & Margin: Dolphins by 5.6 points (Bet on this game at BetMGM)
• Spread: Dolphins -7
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Lions -7.5 vs. Colts

• Matchup: Detroit Lions at Indianapolis Colts
• Projected Winner & Margin: Lions by 12.2 points (Bet on this game at BetMGM)
• Spread: Lions -7.5
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Texans -8.5 vs. Titans

• Matchup: Tennessee Titans at Houston Texans
• Projected Winner & Margin: Texans by 16.6 points (Bet on this game at BetMGM)
• Spread: Texans -8.5
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Commanders -10.5 vs. Cowboys

• Matchup: Dallas Cowboys at Washington Commanders
• Projected Winner & Margin: Commanders by 18.0 points (Bet on this game at BetMGM)
• Spread: Commanders -10.5
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chiefs -11 vs. Panthers

• Matchup: Kansas City Chiefs at Carolina Panthers
• Projected Winner & Margin: Chiefs by 20.3 points (Bet on this game at BetMGM)
• Spread: Chiefs -11
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.